The regiment was constituted on 15 October 1921 in the Organized Reserves, part of the
65th Cavalry Division's
160th Cavalry Brigade in the
Sixth Corps Area. It was initiated (activated) in April 1922 with headquarters and 1st Squadron at
Detroit and 2nd Squadron at
Lansing. In July 1929, the regiment was reorganized to add a 3rd Squadron at
Flint. In 1930, regimental officer built the 319th Cavalry Club on property owned by a horse farm near the city. On 3 December 1930, the 2nd Squadron moved to
Kalamazoo, Michigan, and the 3rd Squadron moved to
Jackson, Michigan. On 28 July 1937, the entire regiment was relocated to Detroit. The regiment conducted regular equestrian training in Detroit on the horses of the 1st Squadron,
106th Cavalry Regiment. It conducted summer training at
Fort Sheridan with the 14th Cavalry and some years at
Fort Des Moines. As an alternate form of training, the 319th provided cavalry training to civilians at Fort Sheridan under the
Citizens' Military Training Camp program. Its primary
ROTC feeder school was the
Michigan State College of Agriculture and Applied Science and its designated mobilization training station was Camp Grant. After the United States entered
World War II, the regiment was converted into the 70th Tank Destroyer Battalion on 30 January 1942. The battalion was disbanded on 11 November 1944. == Commanders ==