4,4'-Methylenedianiline

In the industrial production, MDA is produced by reaction of formaldehyde and aniline in the presence of hydrochloric acid. MDA is a common monomer in the synthesis of polymer materials. These include polyamides, polyimides and polyimines. MDA is also used extensively as a precursor to methylene diphenyl diisocyanate (MDI). Here, MDA is treated with phosgene to produce MDI. MDI, in turn, is a precursor to many polyurethane foams. MDA can also be applied as a bidentate (bridging) ligand in the formation of metal-coordination complexes. ==Safety==

MDA is considered a potential occupational carcinogen by the US National Institute for Occupational Safety and Health. The Occupational Safety and Health Administration has set a permissible exposure limit at 0.01 ppm over an eight-hour time-weighted average, and a short-term exposure limit at 0.1 ppm. It is suspected carcinogen. It is included in the "substances of very high concern" list of the European Chemicals Agency (ECHA). The compound was blamed in a mass poisoning in the vicinity of Epping, Essex, United Kingdom during 1965 during which 84 individuals were poisoned through accidental contamination of flour used to make bread. ==Related compounds==

• 4,4'-Thiodianiline • 4,4'-Oxydianiline • Dapsone == References ==