Market4-Acetamido-TEMPO
Company Profile

4-Acetamido-TEMPO

4-acetamido-TEMPO is a stable radical used for oxidation reactions in organic chemistry. It is a derivative of TEMPO, from which it differs by the additional acetamide group.

Preparation
4-acetamido-TEMPO can be prepared from 4-amino-2,2,6,6-tetramethylpiperidine. By reaction with acetic anhydride, the amino group is acetylated, and an acetate salt is formed. The free base can be regenerated with potassium carbonate. Oxidation to the nitroxyl radical occurs with hydrogen peroxide in the presence of sodium tungstate and ethylenediaminetetraacetic acid. == Properties ==
Properties
4-acetamido-TEMPO is a stable radical and exists as a crystalline, orange-colored solid. == Reactions ==
Reactions
4-acetamido-TEMPO is suitable as a catalyst for oxidation reactions. This includes the oxidation of primary amines to nitriles with potassium peroxymonosulfate as the stoichiometric oxidizing agent. Additionally, it can be used to oxidize alcohols to aldehydes and ketones. ==References==
tickerdossier.comtickerdossier.substack.com