4-Aminophenol

4-Aminophenol can be prepared by several routes. One route is hydrogenation of 4-nitrophenol over Raney nickel. :HOC6H4NO2 + 3 H2 → HOC6H4NH2 + 2 H2O The nitrophenol can also be reduced by iron or by stannous chloride. 4-Aminophenol can be produced by reduction of nitrobenzene via the intermediate phenylhydroxylamine, which spontaneously rearranges to 4-aminophenol. :C6H5NHOH → HOC6H4NH2 ==Uses==

4-Aminophenol is a building block used in organic chemistry. Prominently, it is the final intermediate in the industrial synthesis of paracetamol. Treating 4-aminophenol with acetic anhydride gives paracetamol: It is a precursor to amodiaquine, mesalazine, AM404, parapropamol, B-86810 & B-87836 (cf. ). 4-Aminophenol converts readily to the diazonium salt. == References ==