4-HO-MPT

The dose and duration of 4-HO-MPT are listed as "unknown" in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved). In a single trial of 8mg 4-HO-MPT hydrochloride orally from TiHKAL, it was described as producing visual distortion, vertigo, and slight insomnia. ==Interactions==

Pharmacodynamics } formation. Sources: 4-HO-MPT acts as a potent agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. It is a partial or full agonist of the serotonin 5-HT2A receptor, a moderate-efficacy partial agonist of the serotonin 5-HT2B receptor, and a high-efficacy partial agonist of the serotonin 5-HT2C receptor.' The drug has more than an order of magnitude higher potency as an agonist of the serotonin 5-HT2A and 5-HT2B receptors than as an agonist of the serotonin 5-HT2C receptor. It also interacts with other serotonin receptors such as 5-HT6 and 5-HT7 receptors with high affinity and non-serotonergic targets. Additionally it inhibits serotonin transporter.' 4-HO-MPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. ==Chemistry==

Synthesis The chemical synthesis of 4-HO-MPT has been described. Analogues Analogues of 4-HO-MPT include methylpropyltryptamine (MPT), 4-AcO-MPT, 5-MeO-MPT, psilocin (4-HO-DMT), 4-HO-DET (ethocin), 4-HO-DPT (deprocin), 4-HO-MET (metocin), and 4-HO-PiPT (iprocin), among others. ==History==

4-HO-MPT was first described in the scientific literature by David Repke and colleagues in 1981. Subsequently, its effects in humans were described by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). The drug was encountered as a novel designer drug by 2021. ==Society and culture==

Legal status International 4-HO-MPT is not scheduled by the United Nations' Convention on Psychotropic Substances. Canada 4-HO-MPT is not an explicitly nor implicitly controlled substance in Canada as of 2025. United States 4-HO-MPT is not scheduled at the federal level in the United States, but it is possible that 4-HO-MPT could legally be considered an analog of psilocin, in which case, sales or possession with intent for human consumption could potentially be prosecuted under the Federal Analogue Act. == See also ==