5α-Pregnan-17α-ol-3,20-dione

5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen, i.e., it binds to the progesterone receptors. However, 17-OH-DHP is better studied as a metabolic intermediate than a progestogen per se. 17-OH-DHP is the first intermediate product within the androgen backdoor pathway in which 17α-hydroxyprogesterone (17-OHP) is 5α-reduced and finally converted to 5α-dihydrotestosterone (DHT) without testosterone intermediate. The subsequent intermediate products in the pathway are 5α-pregnane-3α,17α-diol-20-one, androsterone and 5α-androstane-3α,17β-diol. The primary feature of the androgen backdoor pathway is that 17α-hydroxyprogesterone (17-OHP) can be 5α-reduced and finally converted to 5α-dihydrotestosterone (DHT) via an alternative route that bypasses the conventional intermediates androstenedione and testosterone. ==Biosynthesis==

5α-Pregnan-17α-ol-3,20-dione is produced by 5α-reduction of 17-OHP. The reaction is catalyzed by SRD5A1 and possibly, SRD5A2 enzymes. Some authors In a later study, conducted in 2017, however, it has been shown that recombinant human SRD5A1 and SRD5A2 can catalyze the reduction of 17-OHP at comparable rates to the reduction of progesterone. Given both isozymes may be expressed in fetal tissues of both sexes, the action of SRD5A2 in this reaction in humans is yet to be established. == See also ==