The 3rd Regiment Arkansas Volunteer Infantry (African Descent) participated in the Expedition from Helena up White River February 4–8, 1864. Colonel Brooks of the 56th was mortally wounded early in the action and Lieutenant Colonel Moses Reed assumed command. The 56th and the other Union forces made their way back to Helena. Union casualties in the battle were 19 killed, 40 wounded, and four missing. Confederate losses are unknown. The 56th Colored Regiment losses during service consisted of: four officers and 21 enlisted men killed or mortally wounded; and two officers and 647 enlisted men by disease; for a total of 674 fatalities. The vast majority of the deaths due to disease occurred during a cholera epidemic that struck in August 1866 while the regiment was waiting to muster out at
Jefferson Barracks Military Post near
St. Louis. One hundred seventy-five African American enlisted men of the 56th U.S. Colored Infantry are buried together in a mass grave at
Jefferson Barracks National Cemetery. ==Mustered out of service==