As part of Cleburne's brigade, in General
William J. Hardee's Third Army Corps, the 6th Mississippi took part in the
Battle of Shiloh on April 6–7, 1862. On the morning of April 6 the Regiment advanced against the Union lines at Rhea field alongside the
23rd Tennessee Infantry Regiment, but their advance was impeded by a bog and the obstacles of the Federal camp. 60 men of the Regiment reformed ranks for a counterattack led by Captain A.Y. Harper, The 6th Regiment suffered a 76% casualty rate at Shiloh, earning it the nickname of "The Bloody Sixth". A monument to the 6th Mississippi was dedicated at
Shiloh National Military Park in 2015, located at Rhea field where the troops of the Regiment fell in battle. After Shiloh, the Regiment was sent to camp at Corinth and reorganized. Colonel Thornton resigned,
Robert Lowry was elected as the new Colonel, and A.Y. Harper was promoted to Lieutenant Colonel. The Regiment was assigned to General
John S. Bowen's brigade in Major General
John C. Breckinridge's reserve corps and transferred to a supporting position near
Vicksburg, Mississippi in the summer of 1862. ==Vicksburg and Knight Company==