Akkineni was very active in social service. Regarding the existence of God, he once said, "If there's a presence there, I'm sure he'll want us to perform our earthly duties well and be a good human being rather than blindly worship him". Akkineni set up the Akkineni Janmabhoomi trust under the Janmabhoomi programme to foster development in his home town,
Ramapuram. He was instrumental in the construction of the Akkineni Varadhi (a bridge named after him), which improved his village's economy by facilitating easy connectivity. In Ramapuram, Akkineni contributed towards the construction of a water filtration plant. He instituted the Akkineni International Foundation in 2005 to honour those who contributed to the Film Industry. The
Annapurna College of Film and Media, founded by his family in 2011, was set up as a non-profit entity. Rao donated to educational institutions since the beginning of his career and created scholarships at
GITAM University (Vizag). He was the Chief Donor and President of Akkineni Nageswara Rao College, which was named after him. Rao was a Life member of the board and an adviser to the Department of Dramatics and Theatre Arts of Andhra University. He instituted gold medals for students who excelled in Acting and Direction. In 2012, he instituted the Akkineni Annapurna Educational Trust in memory of his wife Annapurna. ==Personal life==