The club was founded in 1927, playing also in
Serie C for 20 seasons. The club's best results occurred in the 1990s under the guidance of sporting director
Pantaleo Corvino, and was also the debut team of a 16-year old
Fabrizio Miccoli. In the 2001–02 season,
Mario Kempes, the world-famous Argentine striker, briefly served as head coach for the club. The club was refounded in 2006 as
A.S.D. Virtus Casarano, but in summer 2012 it does not join in Serie D, due to bankruptcy. Immediately after on 24 July 2012, the club was again refounded by
Eugenio Filograna as
S.S.D. Casarano Calcio and was relocated in
Promozione Apulia. In 2025, Casarano were promoted back to Serie C after winning the Group H of the
2024–25 Serie D season. == Colors and badge ==