Rajasekhara Reddy joined
Indian National Congress in 1978 and won the
1978 legislative assembly elections from
Pulivendula. He became minister for Rural Development from 1980 and later shifted to the Excise Ministry in 1982 and Education in 1982–83. He won the
1983 and
1985 elections from the same constituency. In 1989, he was elected to the
Lok Sabha from
Cuddapah. He won from
Kadapa Parliamentary constituency for four terms in
9th,
10th,
11th and
12th Lok Sabha. During his decade-long tenure, his constituencies were well developed with Concrete Roads and drinking water taps in almost every streets. Over the two decades of his career, His family ran several colleges in Pulivendla but the institutions were eventually handed over to
Loyola College as no one in the family had time to run them. In 2003, he undertook a three-month-long
padayatra covering in 60 days across 11 districts of Andhra Pradesh as a part of his election campaign. In a protest against assassination plot for then
Chief Minister of Andhra Pradesh Nara Chandrababu Naidu, He underscored the point that the "State bureaucracy had become complacent".
Chief Ministership (2004–09) Reddy led the congress party to victory in the
2004 assembly election and served as the 14th
Chief Minister of Andhra Pradesh from 2004 to 2009. During his tenure as Chief Minister, he enacted schemes to provide
free electricity for farmers, a
health insurance program for rural people living below the
poverty line, a free public ambulance service, low interest loans to rural women, subsidised housing for the rural poor, subsidized rice, reimbursement of college fees for underprivileged and reservation for minorities. His tenure also saw the weakening of the violent extremist left-wing
Naxalite movement that was rampant in the state.
Aarogyasri Scheme Apart from the last three 5 year plans, which advocated PPP in health-care, other factors led to starting of Aarogyasri in AP. Jayati Ghosh committee on the farmer's suicide in AP brought out the precarious health conditions due to economic distress in the agriculture sector and suggested free care of the poor by the private hospitals, which have benefitted from state subsidies. These recommendations of the report became convenient support to him, being a medical doctor himself, to provide this innovative health-care scheme for all, through corporate hospitals. Earlier CM relief fund had spent Rs. 168.52 crores to help 55,362 below the poverty line (BPL) patients needing hospitalization. Simultaneously, Dalit movement highlighted problems of young children with heart ailments in the state. Soon, He announced free heart surgeries for these children, by August 2006, 4600 children were operated under the CM relief fund. This magnanimous gesture set the stage for Aarogyasri scheme.
Second term as the Chief Minister of Andhra Pradesh (2009) He led the congress party to victory in the
2009 assembly election, winning 156 seats in the assembly. He became the first incumbent chief minister from Congress since 1969 (after
Kasu Brahmananda Reddy in 1969) to win and was sworn in as the 15th
Chief Minister of Andhra Pradesh on 20 May 2009. He termed the results the "people's victory" and vowed to continue welfare and development schemes, especially construction of irrigation project'. ==Disappearance and death==