His career spanned almost four decades from 1929 to the late 1960s. In the 1950s, he along with 10 other practising architects including two foreigners;
M. A. Ahed, Tajuddin Bhamani, Minoo Mistry, Pir Mohammad,
R. S. Rustomji, H. H. Khan,
Mehdi Ali Mirza, Zahiruddn Khawaja, Bloomfield and Peter Powell, formed the
Institute of Architects, Pakistan. He established his own practice, Abdulhusein M. Thariani in Bombay in 1929. Amongst his works in the city is the Ambassador Hotel. After the
creation of Pakistan as an independent state in 1947, he moved to Karachi and joined M/s Hyderi Construction Company as its managing director. Under his direction, the first
textile mill of Pakistan, Valika Textile Mills, in
S.I.T.E. was constructed. In the early 1950s he left the company to restart his own practice under the name of Thariani & Co. ==Projects==