;Independent career In July 2008, Doyle was appointed as an assistant professor of chemistry at Princeton University. She was promoted to the rank of associate professor with tenure in 2013, and to full Professor with an endowed chair, the A. Barton Hepburn Professor of Chemistry, in 2017. In 2021, she moved to the
University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry. She studies catalysis and physical organic chemistry. In 2021 She was selected as one of the Cell Press 50 scientists.
Research Her lab, the Doyle Lab Group, specializes in organic, computational, and physical organic chemistry. One of the group's main priority is to solve problems that the field has with organic synthesis by creating catalytic reactions and synthetic processes. A longstanding research interest of the Doyle group is the development of nickel-catalyzed C–C bond forming reactions that utilize unconventional cross-coupling electrophiles, such as epoxides, aziridines, imminium ions, and oxocarbenium ions. The group has developed and mechanistically interrogated new ligands and pre-catalysts for nickel, which have helped to enable these transformations. In collaboration with
David MacMillan's group, the Doyle lab identified a new cross-coupling paradigm which allows the combination of photoredox and nickel catalysis. The Doyle lab has subsequently applied Nickel/photoredox catalysis to methodologies involving both unconventional and traditional cross-coupling electrophiles. The group has also been involved in the development of nucleophilic fluorination chemistry allowing the creation of pharmaceutically relevant molecules with sp3-C-F and sp2-C-F bonds. These methods have employed both transition metal and photoredox catalysis, and the group has developed new reagents for mild and selective deoxyfluorination reactions. Recently, the Doyle group has worked in the area of data science-driven analysis of chemical reactions, including the implementation of machine learning algorithms to model and predict reaction outcome in organic chemistry. Her most recent publication is on the "Markovnikov hydroamination of terminal alkenes via phosphine redox catalysis," published in the Nature journal. Doyle's lab has also been utilizing these computer-assisted techniques as an aid to improve the design of their catalysts as well as the exploration of new reactions. Early on in 2026, Doyle had the opportunity to co-lead a research team alongside her research partner Mathew S. Sigman. Together they were able to create a prediction system which used learned based functions to help accelerate the processes of drug discovery. This study focused on the predictions of nickel-catalyzed reaction outcomes. == Awards and honors ==