Mamatziolas started his career from the amateur team Propontida Thessaloniki. In 1989 he signed with
PAOK. He played eight years with PAOK and he won the
1990–91 FIBA European Cup Winners' Cup, 1
Greek League (1992), the
1993–94 FIBA Korać Cup, and 1
Greek Cup (1995). His best game in his career was a play-off game against
Panathinaikos in 1997. PAOK won the game with 90-85, and Mamatziolas end the game with 29 points and 100% hit. He has 2/2 free throws, 6/6 two-points, and 5/5 three-points. Mamatziolas moved to Iraklis the same year, as an exchange for
Lefteris Kakiousis transfer. He also, played with
Iraklio B.C.,
Gymnastikos S. Larissas B.C. and
G.S. Olympia Larissa B.C. ==National team career==