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Actinomycetota

The Actinomycetota are a diverse phylum of Gram-positive bacteria with high guanine-cytosine content. They can be terrestrial or aquatic. They are of great importance to land flora because of their contributions to soil systems. In soil, they help decompose organic matter of dead organisms so the molecules can be taken up anew by plants. While this role is also played by fungi, actinomycetota are much smaller and likely do not occupy the same ecological niche. In this role, the colonies often grow extensive mycelia, as fungi do, and the name of an important order of the phylum, Actinomycetales, reflects that they were long believed to be fungi. Some soil actinomycetota live symbiotically with the plants whose roots pervade the soil, fixing nitrogen for the plants in exchange for access to some of the plant's saccharides. Other species, such as many members of the genus Mycobacterium, are important pathogens.

General
Most actinomycetota of medical or economic significance are in class Actinomycetia, and belong to the order Actinomycetales. While many of these cause disease in humans, Streptomyces is notable as a source of antibiotics. Actinomycetota, especially Streptomyces spp., are recognized as the producers of many bioactive metabolites that are useful to humans in medicine, such as antibacterials, antifungals, antivirals, antithrombotics, immunomodifiers, antitumor drugs, and enzyme inhibitors; and in agriculture, including insecticides, herbicides, fungicides, and growth-promoting substances for plants and animals. Actinomycetota-derived antibiotics that are important in medicine include aminoglycosides, anthracyclines, chloramphenicol, macrolides, tetracyclines, etc. Actinomycetota have high guanine and cytosine content in their DNA. The GC content of actinomycetota can be as high as 70%, though some may have a low GC content. Analysis of glutamine synthetase sequence has been suggested for phylogenetic analysis of the Actinomycetota. ==Phylogeny==
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). ==See also==
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