MarketAcylsilane
Company Profile

Acylsilane

Acylsilanes are a group of chemical compounds sharing a common functional group with the general structure RC(O)-SiR3.

Synthesis
Acylsilanes can be synthesized by treating acyl anion equivalents with silyl halides (typically trimethylsilyl chloride, tmsCl). Silylation of 2-lithio-1,3-dithiane, followed by hydrolysis of the dithioacetal group with mercury(II) chloride. Analogous methods has also been used to produce acylgermanes. Several approaches to acylsilanes start with carboxylic acid derivatives. ==Reactions==
Reactions
Acylsilanes are starting compounds in the Brook rearrangement with vinyl lithium compounds to silyl enol ethers. Acyl silanes and aryl bromides are coupling partners in Pd-catalyzed cross coupling reactions: ==Further reading==
tickerdossier.comtickerdossier.substack.com