This gene encodes the enzyme responsible for
pre-mRNA editing of the
glutamate receptor subunit B by site-specific
deamination of
adenosines. Studies in rats found that this enzyme acted on its own
pre-mRNA molecules to convert an
AA
dinucleotide to an A
I dinucleotide which resulted in a new
splice site.
Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an
Alu cassette insert and a short or long
C-terminal region. ADARB1 is an
A-to-I RNA-editing enzyme that mostly acts on
protein-coding substrates. == See also ==