Claus mostly worked in organic chemistry where his interests were very diverse and included
alkaloids,
aromatic substitution, oximes and theoretical considerations on the structure of organic molecules. Claus is best known for proposing a model of
benzene molecule in 1867. It took years of research before the three postulated structures of benzene – by
Albert Ladenburg (1869),
August Kekulé 1865 and by Claus – found their place in organic chemistry. Ladenburg's
prismane and
Claus' benzene were both proven to be wrong. While the prismane was synthesized in 1973, calculations showed that the synthesis of
Claus' benzene is impossible. Claus synthesized and determined the structure of several
isomers of
oximes. He described the isomerism by differences in the bond structure of the molecules whereas several other scientists found it more convincing to describe the difference by the relatively new concept of
stereochemistry. This scientific dispute lasted until his death in 1900. ==References==