In the early 1920s, T. F. Jackson opened a two-room
clinic on the second floor of the Touchton building in
Dade City, Florida. In late October 1926, he purchased the former
house of Reverend H. N. Abraham for his practice. Over the years several wings were added. In 1961, the older portion of the hospital was
demolished. In 1999, East Pasco Medical Center expanded its
emergency department, before it was expanded the hospital rejected patients, forcing them to go to
Columbia Dade City Hospital. On January 1, 2006, East Pasco Medical Center
rebranded to Florida Hospital Zephyrhills. In early October 2012, the hospital opened the Simpson Breast Health Center, the facility is named after a local that donated $250,000 to the hospital's foundation. On January 2, 2019, Florida Hospital Zephyrhills rebranded to AdventHealth Zephyrhills. On January 1, 2021, all hospitals were required to have their
chargemaster on its
website by the
Centers for Medicare & Medicaid Services. In a
survey done in 2022, the majority of hospitals in Florida including AdventHealth Zephyrhills had failed to comply with the Hospital Price Transparency Law. It was not until early February 2023, that the hospital was in full compliance with the law. In March 2024, AdventHealth Zephyrhills and
Saint Leo University partnered to create a dedicated education unit to fill the nursing shortage in the state. On August 29, 2025, there was a groundbeaking for a
medical office building,
HuntonBrady Architects was hired to design it and
Robins & Morton to build it. On March 4, 2026, the building was
topped out. ==Awards and recognitions==