Seasonal affective disorder

SAD is a type of major depressive disorder, and those with the condition may exhibit any of the associated symptoms, such as feelings of hopelessness and worthlessness, thoughts of suicide, loss of interest in activities, withdrawal from social interaction, sleep and appetite problems, difficulty with concentrating and making decisions, decreased libido, a lack of energy, or agitation. SAD is typically associated with winter depression, but springtime lethargy or other seasonal mood patterns are not uncommon. Although each individual case is different, in contrast to winter SAD, people who experience spring and summer depression may be more likely to show symptoms such as insomnia, decreased appetite and weight loss, and agitation or anxiety. It is important to distinguish between diagnoses because there are important treatment differences. In these cases, people who have the With seasonal pattern specifier may experience a depressive episode either due to major depressive disorder or as part of bipolar disorder during the winter and remit in the summer. Differences in biological sex display distinct clinical characteristics associated to seasonal pattern: males present with more Bipolar II disorder and a higher number of depressive episodes, and females with rapid cycling and eating disorders. Those with ADHD and SAD are likely to experience sluggishness, irritability, and withdrawal. A study published in the Journal of Affective Disorders found that approximately 27% of adults with ADHD also experience SAD, with women being more susceptible than men. ==Cause==

In many species, activity is diminished during the winter months, in response to the reduction in available food, the reduction of sunlight (especially for diurnal animals), and the difficulties of surviving in cold weather. Hibernation is an extreme example, but even species that do not hibernate often exhibit changes in behavior during the winter. Various proximate causes have been proposed. One possibility is that SAD is related to a lack of serotonin, and serotonin polymorphisms could play a role in SAD, although this has been disputed. Mice incapable of turning serotonin into N-acetylserotonin (by serotonin N-acetyltransferase) appear to express "depression-like" behavior, and antidepressants such as fluoxetine increase the amount of the enzyme serotonin N-acetyltransferase, resulting in an antidepressant-like effect. Another theory is that the cause may be related to melatonin, which is produced in dim light and darkness by the pineal gland, Melatonin secretion is controlled by the endogenous circadian clock, but can also be suppressed by bright light. ==Pathophysiology==

Seasonal mood variations are believed to be related to light. An argument for this view is the effectiveness of bright-light therapy. SAD is measurably present at latitudes in the Arctic region, such as northern Finland (around 64 degrees north latitude), where the rate of SAD is 9.5%. Cloud cover may contribute to the negative effects of SAD. There is evidence that many patients with SAD have a delay in their circadian rhythm, and that bright light treatment corrects these delays which may be responsible for the improvement in patients. The symptoms of it mimic those of dysthymia or even major depressive disorder. There is also potential risk of suicide in some patients experiencing SAD. One study reports 6–35% of people with the condition required hospitalization during one period of illness. The blue feeling experienced by both those with SAD and with SSAD can usually be dampened or extinguished by exercise and increased outdoor activity, particularly on sunny days, resulting in increased solar exposure. Connections between human mood, as well as energy levels, and the seasons are well documented, even in healthy individuals. ==Diagnosis==

According to the American Psychiatric Association DSM-IV criteria, Seasonal Affective Disorder is not regarded as a separate disorder. It is called a "course specifier" and may be applied as an added description to the pattern of major depressive episodes in patients with major depressive disorder or patients with bipolar disorder. The "Seasonal Pattern Specifier" must meet four criteria: depressive episodes at a particular time of the year; remissions or mania/hypomania at a characteristic time of year; these patterns must have lasted two years with no nonseasonal major depressive episodes during that same period; and these seasonal depressive episodes outnumber other depressive episodes throughout the patient's lifetime. The Mayo Clinic describes three types of SAD, each with its own set of symptoms. ==Management==

Treatments for classic (winter-based) seasonal affective disorder include light therapy, medication, cognitive-behavioral therapy, and carefully timed supplementation of the hormone melatonin. Light therapy Photoperiod-related alterations of the duration of melatonin secretion may affect the seasonal mood cycles of SAD. This suggests that light therapy may be an effective treatment for SAD. Light therapy uses a lightbox, which emits far more lumens than a customary incandescent lamp. Bright white "full spectrum" light at 10,000 lux, blue light at a wavelength of 480nm at 2,500 lux or green (actually cyan or blue-green) light at a wavelength of 500nm at 350 lux are used, with the first-mentioned historically preferred. Bright light therapy is effective Discovering the best schedule is essential. One study has shown that up to 69% of patients find lightbox treatment inconvenient, and as many as 19% stop use because of this. Patients using light therapy can experience improvement during the first week, but increased results are evident when continued throughout several weeks. Most studies have found it effective without use year round, but rather as a seasonal treatment lasting for several weeks, until frequent light exposure is naturally obtained. or using a computer-controlled heliostat to reflect sunlight into the windows of a home or office. Although light therapy is the leading treatment for seasonal affective disorder, prolonged direct sunlight or artificial lights that don't block the ultraviolet range should be avoided, due to the threat of skin cancer. The evidence base for light therapy as a preventive treatment for seasonal affective disorder is limited. The decision to use light therapy to treat people with a history of winter depression before depressive symptoms begin should be based on a person's preference of treatment. Both fluoxetine and light therapy are 67% effective in treating SAD, according to direct head-to-head trials conducted during the 2006 Can-SAD study. Subjects using the light therapy protocol showed earlier clinical improvement, generally within one week of beginning the clinical treatment. In a 2021 updated Cochrane review of second-generation antidepressant medications for the treatment of SAD, a definitive conclusion could not be drawn, due to lack of evidence, and the need for larger randomized controlled trials. Vitamin D supplementation may help correct common deficiencies in people with winter-pattern SAD and can complement other treatments, but evidence for it as a standalone therapy is mixed and inconclusive. Other treatments Depending upon the patient, one treatment (e.g., lightbox) may be used in conjunction with another (e.g., medication). One particular study noted marked effectiveness for treatment of depressive symptoms, when combining regular exercise with bright light therapy. Patients exposed to exercise which had been added to their treatments in 20 minutes intervals on the aerobic bike during the day, along with the same amount of time underneath the UV light were seen to make a quick recovery. Of all the psychological therapies aimed at the prevention of SAD, cognitive-behavior therapy, typically involving thought records, activity schedules and a positive data log, has been the subject of the most empirical work. However, evidence for cognitive behavioral therapy or any of the psychological therapies aimed at preventing SAD remains inconclusive. ==Epidemiology==

Nordic countries Winter depression is a common slump in the mood of some inhabitants of most of the Nordic countries. Iceland, however, seems to be an exception. A study of more than 2000 people there found the prevalence of seasonal affective disorder and seasonal changes in anxiety and depression to be unexpectedly low in both sexes. The study's authors suggested that propensity for SAD may differ due to some genetic factor within the Icelandic population. A study of Canadians of wholly Icelandic descent also showed low levels of SAD. It has more recently been suggested that this may be attributed to the large amount of fish traditionally eaten by Icelandic people. In 2007, about 90 kilograms of fish per person was consumed per year in Iceland, as opposed to about 24 kilograms in the US and Canada, rather than to genetic predisposition; a similar anomaly is noted in Japan, where annual fish consumption in recent years averages about 60 kilograms per capita. Fish are high in vitamin D. Fish also contain docosahexaenoic acid (DHA), which helps with a variety of neurological dysfunctions. Other countries In the United States, a diagnosis of seasonal affective disorder was first proposed by Norman E. Rosenthal, M.D. in 1984. Rosenthal wondered why he became sluggish during the winter after moving from sunny South Africa to (cloudy in winter) New York. He started experimenting with increasing exposure to artificial light, and found this made a difference. In Alaska it has been established that there is a SAD rate of 8.9%, and an even greater rate of 24.9% for subsyndromal SAD. Around 20% of Irish people are affected by SAD, according to a survey conducted in 2007. The survey also shows women are more likely to be affected by SAD than men. An estimated 3% of the population in the Netherlands experience winter SAD. Mexico reports an increase in SAD symptoms during the winter months, noting that reduced sunlight exposure and pollution may contribute to these mood disturbances. == History ==

Research on SAD in the United States began in 1979 when Herb Kern, a research engineer, noticed he felt depressed during the winter months. Kern suspected that scarcer natural light in winter was the cause and discussed the idea with NIMH scientists working on bodily rhythms. They were intrigued and responded by inventing a lightbox to treat Kern's depression, which improved. SAD was formally described and named in 1984 by Norman E. Rosenthal and his colleagues at the National Institute of Mental Health. The initial investigation was motivated by observations of depression occurring during the dark winter months in northern regions of the United States, known as polar night. Rosenthal proposed that the reduction in available natural light during winter could contribute to this phenomenon. Subsequently, he and his colleagues conducted a placebo-controlled study that utilized light therapy to document the effects of the condition. has become the standard introduction to the subject. SAD is usually more common in the fall/winter (Winter SAD), though it may occur during the spring/summer (Spring SAD). Winter-onset SAD is more common and is often characterized by atypical depressive symptoms including hypersomnia, increased appetite, and craving for carbohydrates. Spring/summer SAD is also seen and is more frequently associated with typical depressive symptoms including insomnia and loss of appetite. == Criticism of disorder and diagnosis ==

The validity of SAD has been called into question multiple times. A 2008 study indicated that some people stay without sun for months, yet they are not affected by SAD. A 2016 analysis from the Centers for Disease Control found no links between depression, seasonality or sunlight exposure and suggested discontinuation of the diagnosis. Further, a 2018 study focusing on instability of SAD diagnosis criteria over prolonged periods of time, suggested that SAD is a temporary expression of a mood disorder rather than a specific disorder. == See also ==