The airline was incorporated on 6 March 1964, founded by Albert Briand. Services commenced in June with a cooperation with Eastern Provincial Airways, allowing
codesharing with EPA's
Douglas DC-3 between Saint-Pierre and Sydney. However, the codesharing was terminated in October. Air Saint-Pierre thereafter started conducting charter flights with a Piper Aztec. A second unit was procured in 1966, the same year as the founder died. The airline continued its cooperation with EPA, including hiring the latter for maintenance. The Saint-Pierre to Sydney route resumed under operation of Air Saint-Pierre in 1971. At first they flew using a Beechcraft Model 18, and three years later this was increased to flights using a DC-3. In 1976 the DC-3 was sold and replaced with a Hawker Siddeley HS 748. Miquelon Airport opened in 1979, allowing Air Saint-Pierre to commence an inter-island service to the larger island of
Miquelon-Langlade. The same year the pooling between EPA and Air Saint-Pierre resumed on the Saint-Pierre to Sydney route. This allowed the Chieftain to be decommissioned the following year. The initial ATR was sold in 2009 and replaced on 21 October with a newer and more modern
ATR 42-500. == Destinations ==