Muhammed-Oyebode had her national youth service at the Ministry of External Affairs in Lagos between 1988 and 1989. She began her career as an associate at the firm of Ajumogobia, Okeke, Oyebode & Aluko in Lagos in 1989. In 1991, she established Asset Management Group Limited, a real estate development company. She was also a non-executive director of
Diamond Bank Nigeria. In 2017, she was appointed as a board member of the Women's Leadership Board of the Women and Public Policy Program at the
Harvard Kennedy School,
Cambridge, Massachusetts. Other board memberships include as Board Chair,
Lekoil Nigeria Limited == Philanthropy/activism ==