SR 157 begins at a 4-way stop with US 278. South of the 4-way stop, the road continues as Cullman County Road 719. Following a four-lane (undivided and divided) northern bypass of
Cullman, the route serves as a retail strip, intersecting
U.S. 31 and
Interstate 65. West of the Interstate, the route immediately ruralizes, meandering across
Brindley Mountain. After descending into the Moulton Valley, the route straightens, following a mostly flat routing to outside
Moulton. After narrowing to an undivided highway, the route serves the retail district of Moulton, crossing the divided
SR 24. Leaving the city limits, the route widens back into a divided highway. After weaving across the upper ridges of the Moulton Valley, the route descends into the
Tennessee Valley, continuing onward to an limited intersection with
U.S. 72 Alternate outside
Muscle Shoals. After a concurrency with U.S. 72 Alternate, the route turns north with
SR 133, crossing the
Tennessee River at the
Singing River Bridge. Continuing north, SR 133 turns onto Veterans Drive while SR 157 continues as Helton Drive while skirting the edge of downtown
Florence. After crossing
U.S. 72/
U.S. 43, the route intersects SR 133 once again on the north side of the city. In its second concurrency with SR-133 (as Cox Creek Parkway), the route heads west before turning onto Cloverdale Road. The route leaves incorporated areas, continuing north as a two-lane highway to the
Tennessee state line. ==History==