From its creation in 1955 to 1965, US-278 followed a very different route from
Whitehouse to
Double Springs. It followed
SR-129 from Whitehouse to
Haleyville; In Haleyville, the route followed
SR-13 to
SR-195. It would then follow SR-195 to Double Springs, where it would turn onto its present-day routing. Oddly, State Route 74 followed the present day routing between the two cities via
Natural Bridge from 1956 onward. The routing of U.S. Route 278 in between Double Springs and Cullman has witnessed several minor changes from 1955 to the present day. From its creation until around 1982, the route followed present-day Winston County Roads 3800 and 3700, crossing Brushy Creek at a now-abandoned bridge before climbing up to join its present-day route into
Addison. On the east side of Addison, the route followed Main Street, descending down and crossing Rock Creek at another abandoned bridge before rejoining the modern-day route. Both of these routings have been replaced with straighter routings. On the west side of Cullman, the route previously descended down into a hollow where it proceeded to cross Vest Creek before climbing up the hollow and rejoining the modern-day routing; this routing was replaced in 2012 with a much straighter bridge across the same creek. Until at least 1997, the route followed 4th Street into Cullman, where it engaged in a short concurrency with U.S. Route 31 before rejoining the modern-day route; this was replaced with the modern-day routing along 3rd Street. During the 1960s–1980s, there were some different variations of the routing of US 278 through the cities of
Gadsden and
Attalla, however, the construction of four-lane segments on the western side of Gadsden and in Attalla allowed the highway to take its current route which has been in place since the mid-1980s. Until the mid-1980s, a
US 278 Business (US 278 Bus.) existed in the city of
Piedmont. US 278 is carried on a four-lane segment that
bypasses the center of Piedmont. US 278 Bus. began where the four-lane segment began on the northeast side of Piedmont, then traveled southwest into the center of the city and intersected
SR 9 and then traveled to the north,
concurrent with SR 9 until it intersected the four-lane US 278 on the northern edge of the city. ==Future==