Picasso made his professional debut against Jose Antonio Arellano Lopez on March 25, 2017. He won the fight by split decision. On July 15, 2023, he fought Sabelo Ngebinyana for the
WBC Silver super-bantamweight title. Picasso won the fight by technical knockout in the sixth round. On July 19, 2024, it was announced that Picasso would defend his title against
Azat Hovhannisyan on the
Mayweather-Gotti III undercard on August 24, 2024. He won the fight by unanimous decision. On July 19, 2025 at
MGM Grand Garden Arena in
Paradise, Nevada, Picasso fought
Kyonosuke Kameda on the undercard of
Manny Pacquiao-Mario Barrios undercard, winning by majority decision. On December 27, 2025, he challenged undisputed super-bantamweight champion
Naoya Inoue at the
Mohammed Abdo Arena in
Riyadh, Saudi Arabia. Picasso lost by unanimous decision to suffer his first professional defeat. ==Professional boxing record==