Early career Born in
Trescore Balneario, Brignoli was loaned to
Ternana Calcio for 2012–13 season. He made his professional debut on 1 September 2012, starting in a 0–1 home loss against
Modena for the
Serie B championship. On 31 January 2013, Ternana signed Brignoli outright from Lumezzane. He continued to appear regularly for the club, achieving mid table positions in all campaigns.
Juventus On 2 February 2015,
Juventus signed Brignoli outright for €1.75 million, which saw the remaining 50% registration rights of
Alberto Masi move in the opposite direction for €1.5 million. Brignoli returned to
Terni immediately on loan for the rest of the season.
Sampdoria On 2 July 2015, Brignoli was signed by
Sampdoria in a temporary deal. He made his
Serie A debut on 14 May 2016 (round 38 the last round), playing the full 90 minutes in a 0–5 away loss against his parent club.
CD Leganés On 20 July 2016, Brignoli was loaned to
La Liga club
CD Leganés, for one year.
Perugia On 11 January 2017, Brignoli returned to Italy, joining
Perugia on loan.
Benevento On 30 July 2017, Brignoli joined Serie A newcomers
Benevento on a temporary deal, with an obligation to buy at the end of season. According to
Corriere dello Sport – Stadio, the obligation would depend on Benevento securing a place in the 2018–19 Serie A season. On 3 December, he scored a 95th-minute equaliser with a header in a 2–2 home draw against
Milan, to earn Benevento their first ever point in Serie A after a record 14 consecutive defeats. With the goal, Brignoli was the third goalkeeper to score from open play in Serie A history after
Michelangelo Rampulla in 1992 and
Massimo Taibi in 2001.
Palermo On 25 July 2018, Brignoli signed with
Serie B club
Palermo until 30 June 2021.
Empoli On 18 July 2019, Brignoli signed for
Serie B club
Empoli for free. On 20 September 2021, Alberto Brignoli became the best goalkeeper in last year's
Serie B as he helped his team, Empoli, rise to
Serie A.
"It was a great pleasure and honor to receive the award for best goalkeeper for last season. I want to thank my teammates, my coaches and the staff who gave me the opportunity to catch this performance." Panathinaikos On 31 August 2021, Brignoli joined Greek club
Panathinaikos on a
free transfer. On 13 January 2024, Panathinaikos announced that Brignoli would depart the club upon the expiry of his contract in the forthcoming summer.
AEK Athens On 2 July 2024, Brignoli joined Greek club
AEK Athens on a
free transfer. ==Career statistics==