Both of Cross's parents died while he was a child, his mother to lung cancer and his father to alcoholism. He was sent to live with his grandmother, Nana Mama, in Washington, D.C. when he was nine years old. In adulthood he would go on to obtain a
Ph.D. in
Psychology from
Johns Hopkins University and work for the
Washington, D.C. Police Department and the
Federal Bureau of Investigation (FBI). Cross is also a former boxer, which has aided him when forced to fight with violent criminals. Cross has had three major romantic relationships throughout the course of the
Alex Cross series and its adaptations. Prior to the series' start Cross met and married a woman named Maria, who was assassinated prior to the events of
Along Came a Spider (1993) and with whom he had two children. A second major love interest, Christine Johnson, was introduced in
Cat and Mouse (1997), and the two had a child together before the relationship ended due to the dangers and stress of Cross's job. A new love interest, Bree Stone, is introduced in
Double Cross (2007). Other people in Cross's life include his troubled adopted daughter Ava, who was murdered by a nemesis in
Alex Cross, Run (2013). Cross has also held a long friendship with his partner and best friend
John Sampson. As the series progresses Cross meets and deals with several cases, including Kyle "The Mastermind" Craig, who serves as a primary antagonist for the series. Craig, along with other antagonists and the general stress and danger of his job, causes Cross to constantly struggle for a balance between his role as a detective and his responsibilities as a father, friend, and romantic partner. == Appearances in series ==