Nisenson began acting professionally at the age of eight years old and made in 2015 her television debut on
NBC's
Constantine as Geraldine Chandler. A year later, in October 2016, she made her feature film debut in the film
Middle School: The Worst Years of My Life. For her role in this film, she received in 2017 an award in the category
Best Performance in a Feature Film – Supporting Young Actress at the
38th edition of the
Young Artist Award. After this she appeared in the film
Fist Fight, and in the television series
Good Behavior and
Will & Grace. In April 2018, Nisenson made her debut as the character Charlie in the
AMC post-apocalyptic horror drama television series
Fear the Walking Dead. Her character was a recurring character in the fourth season, but was promoted to series regular for season five. She was seen as a regular until the end of season seven in 2021. She made a one-time return in season eight in 2023. In between, from July 2018 to August 2023, Nisenson provided the voice of Alexa Mongello on the
Cartoon Network series
Summer Camp Island. She also appeared in the lead role of Shelly in the film
Orphan Horse in 2018, starring alongside
Academy Award-winner
Jon Voight. Following this, Nisenson provided the voice of Jess in the podcast series
Discovering Dad in 2024 and played the role of Young Harriet Parker in the
CBS series
NCIS in 2025. == Filmography ==