Misharin became a member of the United Russia political party, rising to membership in the party's General Council. Russian President
Dmitry Medvedev nominated Misharin as candidate for Governor of Sverdlovsk Region position, and the regional Duma (legislature) confirmed his nomination, making him regional governor on November 17, 2009. As regional governor, Misharin was involved in the creation of so-called
Titanium Valley, a special economic zone and industrial park that will make products for the aircraft, automotive, shipbuilding and medical industries. He proposed construction of a high-speed railway connecting Moscow and Yekaterinburg and another between Yekaterinburg and Nizhniy Tagil, an industrial city about 150 km (100 miles) apart. Misharin established and developed long-term international relationships related to commerce, investment, and culture; for example, he developed a strategical contact with
American Chamber of Commerce in Russia, and the leading economic partner of the Oblast is Germany. In December 2011
Standard & Poor's credit rating service promoted the Sverdlovsk region's long-term rating from BB to BB+ with a stable outlook. Misharin ordered construction of the Ekaterinburg-Expo exhibition center to hold the second
Innoprom exhibition. The project ran over budget, and half of the construction was abandoned. Innoprom 2011 was held in the completed part of the complex. After Russia’s bid to host the 2018 FIFA World Cup won, Misharin promoted Yekaterinburg as a host city for elimination-round games and FIFA granted the city host status in September 2012. He overturned the membership of his administration twice while he was governor, and also attempted to combine the two legislative houses into one. Misharin resigned on May 14, 2012. His two and a half years as governor were marked by scandal. ==Awards and medals==