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Nor-LSD

Nor-LSD, or norLSD, also known as N,N-diethyl-6-norlysergamide or as N-desmethyllysergic acid diethylamide (N-desmethyl-LSD), is a serotonin receptor modulator and putative psychedelic of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the methyl group at the 6 position of the ergoline ring system has been removed.

Use and effects
According to Alexander Shulgin, nor-LSD showed no psychedelic effects at assessed doses of up to 500μg in humans, whereas LSD was active at doses as low as 50μg. Higher doses of nor-LSD do not appear to have been assessed. ==Pharmacology==
Pharmacology
Pharmacodynamics Nor-LSD showed 5- to 29-fold lower affinity for the serotonin 5-HT2 receptor compared to LSD (Ki = 30–158nM vs. 5.4nM, respectively). Nor-LSD failed to completely substitute for LSD in rodent drug discrimination tests even at very high doses. Pharmacokinetics Nor-LSD has been reported to occur as a metabolite of LSD in rats and humans. ==Chemistry==
Chemistry
Derivatives Derivatives of nor-LSD substituted at the 6 position include LSD (METH-LAD; 6-methyl), ETH-LAD (6-ethyl), PRO-LAD (6-propyl), BU-LAD (6-butyl), AL-LAD (6-allyl), and PARGY-LAD (6-propynyl), among others. ==History==
History
Nor-LSD was first described in the scientific literature, by Yuji Nakahara and Tetsukichi Niwaguchi, by at least 1971. ==See also==
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