Alexian Brothers Hospital was a Catholic hospital in St. Louis, Missouri, founded in 1869 by the Alexian Brothers, a healing order of Catholic men. In 1870, it began operation as a two-bed facility. In 1874, a larger building was erected. In 1890, a four-story main building was completed, with a fifth floor added in 1897. In 1909, the hospital became affiliated with St. Louis University.