Spyridonidis began his professional career with the
Greek Basket League club
Ilysiakos in 2012. In 2013, he signed a four-year contract with
KAOD. After the team's relegation to the third division, Spyridonidis moved again to
Nea Kifissia. On September 9, 2016, he joined
Koroivos Amaliadas of the
Greek Basket League. After spending two years with Koroivos and due to the team's relegation, Spyridonidis left the club and joined the newly promoted to the
Greek Basket League club
Holargos. Spyridonidis spent the 2019-20 season with
Rethymno Cretan Kings, averaging 1.9 points per game. On October 11, 2020, he joined for
Bisons Loimaa of the Finnish
Koripallon I-divisioona. With Bisons, he won the
Koripallon I-divisioona championship. ==Greek national team==