She previously played for
ACF Firenze and
Fiorentina. Guagni scored her first career hattrick against
Torino Women ASD on 19 January 2013. In summer 2013, Guagni joined
Pali Blues on loan. On 8 July 2020, Guagni was announced at
Atlético Madrid on a three year contract. On 3 January 2022, Guagni was announced at
AC Milan on a one and a half year contract. On 12 August 2024, Guagni was announced at
Como on a one year contract. On 6 May 2025, Guagni announced her retirement from football. She played the last match of her career against
Napoli on 11 May 2025, retiring as Como's captain. ==International career==