Kehoe started her career at the Museum of the Plains Indian in Browning, Montana between the years of 1956 and 1958 as an assistant summer curator. Following her doctoral graduation, she accepted a role as a lecturer at the
University of Saskatchewan, Regina Campus. She held this position for one year, from 1964 to 1965. Kehoe held an assistant professor role at the
University of Nebraska–Lincoln before earning an associate professor role at
Marquette University, both in anthropology. She currently resides in
Milwaukee, Wisconsin, where she has worked as an adjunct professor since her retirement. Kehoe has held offices with the
American Anthropological Association (AAA), the
Society for American Archaeology (SAA), and the
Archaeological Institute of America. She was president of both the
Central States Anthropological Society (CSAS) and the
Association of Senior Anthropologists. She has also worked among Native Americans of
Bolivia at
Lake Titicaca, where she chewed
coca leaves with Native women of the region. nevertheless there remains a community convinced of the stone's authenticity. Kehoe has stated that "The significance of a study of the [Kensington Runestone] is its illumination of struggle between popular knowledge and scientific research. For those who can look at the case, as did Newton Winchell, Robert A. Hall, Jr., and Richard Nielsen, the probability that those Norse were at [Kensington] is a fruitful hypothesis, collating data in new configurations and opening up intriguing new research questions." In 2014, Kehoe published
A Passion for the True and Just: Felix and Lucy Kramer Cohen and the Indian New Deal, a dual biography of
Felix S. Cohen and
Lucy Kramer Cohen. The Cohens, a lawyer and an anthropologist respectively, were instrumental in the research and drafting of the
Indian Reorganization Act and
The Handbook of Federal Indian Law, two landmarks in Native American law in the United States. Her memoir of her career as a woman in American archaeology,
Girl Archaeologist: Sisterhood in a Sexist Profession, was published in 2022 by University of Nebraska Press. == Research focus and fieldwork ==