Following her Ph.D. studies, Piepmeier held the position of associate director of Vanderbilt's Women’s Studies Program. While there, she published the book
Out in Public, which chronicles the lives of women who worked in public in the nineteenth century. Piepmeier was known for her research on third wave
feminist activism. Her 2009 book
Girl Zines: Making Media, Doing Feminism was the first book-length academic study of
zines and women as
zine creators. She co-edited the 2003 anthology
Catching a Wave: Reclaiming Feminism for the 21st Century, a collection which is frequently taught in
women's studies courses. Piepmeier explored how women make reproductive decisions when prenatal testing reveals their fetus has Down syndrome, and analyzed memoirs by parents of children with disabilities. In 2013 she presented at conferences for genetics counsellors and genetics educators, raising questions around the value of eradicating disability from the human population. In addition to her academic writing, she contributed a column for the
Charleston City Paper and had written editorials for
The New York Times Motherlode blog. In these writings Piepmeier covered topics such as same-sex parents, women's rights, raising disabled children and the
Black Lives Matter movement. She also wrote about personal experiences, such as her and her husband's decision to decline pre-natal foetal testing during her pregnancy in 2012, and her fight against cancer from 2015. Piepmeier was President of the Southeastern Women's Studies Association (SEWSA) from 2006 to 2008 and was a member of the Governing Council of the
National Women's Studies Association (NWSA). == Recognition and honors ==