Pristerognathus is an extinct genus of therocephalian, known from the late Middle Permian (Capitanian) of South Africa. It lends its name to the now defunct Pristerognathus Assemblage Zone of the Beaufort Group of South African geological strata. Pristerognathus was a medium-sized therocephalian with a 25 cm (9.8 in) skull and a total length up to 1.5 m.