Altitude training works because of the difference in atmospheric pressure between sea level and high altitude. At sea level, air is denser and there are more molecules of gas per litre of air. Regardless of altitude, air is composed of 21% oxygen and 78% nitrogen. As the altitude increases, the pressure exerted by these gases decreases. Therefore, there are fewer molecules per unit volume: this causes a decrease in partial pressures of gases in the body, which elicits a variety of physiological changes in the body that occur at high altitude. The physiological adaptation that is mainly responsible for the performance gains achieved from altitude training, is a subject of discussion among researchers. Some, including American researchers Ben Levine and Jim Stray-Gundersen, claim it is primarily the increased red blood cell volume. Others, including Australian researcher Chris Gore, and New Zealand researcher Will Hopkins, dispute this and instead claim the gains are primarily a result of other adaptions such as a switch to a more economic mode of oxygen utilization.
Increased red blood cell volume At high altitudes, there is a decrease in oxygen hemoglobin saturation. This hypoxic condition causes
hypoxia-inducible factor 1 (HIF1) to become stable and stimulates the production of
erythropoietin (EPO), a
hormone secreted by the
kidneys, EPO stimulates red blood cell production from
bone marrow in order to increase hemoglobin saturation and oxygen delivery. Some athletes demonstrate a strong red blood cell response to altitude while others see little or no gain in red cell mass with chronic exposure. It is uncertain how long this adaptation takes because various studies have found different conclusions based on the amount of time spent at high altitudes. While EPO occurs naturally in the body, it is also made synthetically to help treat patients with
kidney failure and to treat patients during
chemotherapy. Over the past thirty years, EPO has become frequently abused by competitive athletes through
blood doping and injections in order to gain advantages in endurance events. Abuse of EPO, however, increases RBC counts beyond normal levels (
polycythemia) and increases the viscosity of blood, possibly leading to
hypertension and increasing the likelihood of a
blood clot,
heart attack or
stroke. The natural secretion of EPO by the human kidneys can be increased by altitude training, but the body has limits on the amount of natural EPO that it will secrete, thus avoiding the harmful side effects of the illegal doping procedures.
Other mechanisms Other mechanisms have been proposed to explain the utility of altitude training. Not all studies show a statistically significant increase in red blood cells from altitude training. One study explained the success by increasing the intensity of the training (due to increased heart and respiration rate). In a study comparing rats active at high altitude versus rats active at sea level, with two sedentary control groups, it was observed that
muscle fiber types changed according to
homeostatic challenges which led to an increased metabolic efficiency during the beta oxidative cycle and
citric acid cycle, showing an increased utilization of
ATP for aerobic performance. Due to the lower atmospheric pressure at high altitudes, the air pressure within the breathing system must be lower than it would be at low altitudes in order for inhalation to occur. Therefore, inhalation at high altitudes typically involves a relatively greater lowering of the thoracic diaphragm than at low altitudes. ==See also==