AM-2201 is a
full agonist for
cannabinoid receptors. Affinities are: with a
Ki of 1.0 nM at
CB1 and 2.6 nM at
CB2. The 4-methyl
functional analog MAM-2201 probably has similar affinities. AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces
bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of
JWH-018 in rats, suggesting potent cannabinoid-like activity.
Pharmacokinetics AM-2201
metabolism differs only slightly from that of
JWH-018. AM-2201
N-
dealkylation produces fluoropentane instead of
pentane (or plain
alkanes in general). ==Detection==