After graduation, Donohoe came to the attention of worldwide audiences in 1986 when she was cast to co-star with
Oliver Reed as
Lucy Irvine in
Castaway. She followed this with roles in two
Ken Russell films,
The Lair of the White Worm and
The Rainbow. After moving to Los Angeles in 1990, Donohoe made her debut on television in the role of lawyer Cara Jean "C.J." Lamb on the American television series
L.A. Law in which she appeared during the fifth and sixth seasons of the series. In February 1991, she took part in the first of the so-called "
lesbian kiss episodes" on American television when her character privately kissed fellow lawyer Abby Perkins, played by
Michele Greene. Some of her other television roles include Louise Stoke in Series 8 of
Bad Girls and a guest appearance in
Ally McBeal. She had a major supporting role in the comedy film
Liar Liar (1997), starring
Jim Carrey. Donohoe made her
Broadway debut in a 1995 production of
Uncle Vanya, at the
Circle in the Square Theatre. She returned to the UK to play Mrs. Robinson in a 2001 stage production of
The Graduate. After moving back to the UK in the early 2000s, Donohoe took the role of DI Susan Alembic in the crime drama
Murder City (2004–2006). In 2009 she joined the cast of ITV soap opera
Emmerdale as businesswoman
Natasha Wylde. Donohoe played the character until leaving the series in November 2010. On 18 and 19 February 2010, she was a guest panelist on
Loose Women. She has also lent her voice to the
Activision PC video game
Santa Fe Mysteries: The Elk Moon Murder as Karen Gordon. ==Personal life==