Amanuel started cycling at the age of 14, first with
mountain biking. His first major success was winning the
Eritrean national road race championships in 2014 while riding for a club team. In 2016, he joined , the development team of
UCI WorldTeam , and was selected to join the WorldTeam as a
stagiaire in 2016 and 2017. He joined the team full time the following year, and competed in his first
Grand Tour: the
2018 Vuelta a España where he finished 7th on stage 17 and 34th overall. That season, he also won the
African road race championship. In 2019, he competed in his first
Giro d'Italia and was crowned the
national time trial champion. After folded at the end of the 2020 season, he was signed by with an initial contract lasting through 2022. Amanuel had a strong spring in 2023, finishing second in the
GP Industria & Artigianato di Larciano before competing in the
Giro d'Italia in May. At the Giro, he placed 6th on stage 4 and was presented the
combativity award for the day. However, he ultimately abandoned the race after stage 15. In August, he competed in the
Vuelta a España, attaining a 4th place finish on stage 9. While getting a contract for the 2024 season was initially uncertain, Amanuel renewed his contract with . He had a strong performance in the Giro, doing important domestique work for
Jonathan Milan's successful campaign for the points jersey, as well as making attempts in the breakaway. After his performance in the Giro, his contract was extended through the 2026 season. ==Major results==