On
Halloween 1950, 11-year-old Harvey Pekar refuses to dress up as a
superhero for
trick-or-treating. Years later, Harvey is seen walking the Cleveland streets, and the real Harvey Pekar appears in a documentary-style setup. In 1975, Harvey visits a throat doctor, exhibiting hypochondria. His wife mocks their lifestyle and leaves him. At his file clerk job at a
VA hospital, Mr. Boats offers advice from an
Elinor Wylie poem. In a documentary scene, the real Harvey discusses his part-time used-record collecting/selling. Flashing back to 1962, Harvey meets shy illustrator
Robert Crumb at a yard sale, bonding over jazz and comics. Returning to 1975, the now-famous Crumb visits Cleveland. Frustrated and single, Harvey has a sobering moment in the VA hospital's "deceased" files, leading him to write his own stories. Inspired by an incident at the supermarket, he stays up all night writing. At a diner, Harvey shows Crumb his comic scripts, and Crumb offers to illustrate them. Harvey publishes eight issues of
American Splendor to critical acclaim but little financial gain, remaining a file clerk. He reconnects with Alice Quinn, a former college acquaintance, and they discuss
Theodore Dreiser's novel
Jennie Gerhardt, but he leaves feeling lonelier. Meanwhile, in Delaware, Joyce is frustrated with her partner in the comic book store, who has sold her copy of
American Splendor No. 8. She begins corresponding with Harvey, who eagerly responds. They realize they are kindred spirits, and she travels to Cleveland to meet him. After a dinner date, Joyce becomes ill at his apartment, leading to Harvey's care. Joyce suggests they skip courtship and marry. A week later, Harvey sees his colleague
Toby Radloff eating in his car, heading to
Toledo for a screening of
Revenge of the Nerds. Harvey heads to Delaware to marry Joyce and help her move to Cleveland. The real Joyce Brabner discusses becoming a character in Harvey's stories. Married, Harvey and Joyce attend
Revenge of the Nerds with Toby, which Harvey finds insipid. Back at their apartment, Joyce complains about Harvey's possessions but their argument is interrupted by a theater producer wanting to adapt
American Splendor into a play. After its Los Angeles debut, Harvey's success grows, complicated by Joyce's emotional struggles and desire for children. A producer offers Harvey a guest spot on
Late Night with David Letterman. Harvey's appearances are a hit, and Toby becomes an
MTV star. In Cleveland, Harvey is recognized from
Late Night, rather than
American Splendor, which angers him. Joyce seeks fulfillment and travels to a peace conference without Harvey's permission. One night, Harvey discovers a lump on his groin. With Joyce away, Harvey returns to
Late Night wearing an "On Strike Against NBC" shirt, causing chaos. Joyce returns, discovers Harvey's lump, and he is diagnosed with
lymphoma. She suggests making a comic book about it, but he resists. She enlists Fred, an artist, to illustrate the experience. Fred brings his daughter Danielle, whom Joyce adores. Harvey reluctantly agrees to participate and asks Fred to keep bringing Danielle. Harvey's treatment is grueling. He questions if he is real or a comic character and ponders the story's end if he dies. Harvey dreams of other Harvey Pekars in the phone book. A year later, Harvey and Joyce sign the completed
Our Cancer Year, and he is declared cancer-free. They adopt Danielle, and Harvey adjusts to parenthood. The real Harvey retires from the VA hospital, and the staff holds a retirement party where Joyce, Danielle, and Harvey embrace. ==Cast==