Gledhill started her career in various sketch groups in the north of England. In 2018 it was announced on the
BBC One programme
The One Show that she was the second winner of the
Caroline Aherne Bursary. She received a cash prize and mentoring from a BBC commissioning editor. In 2019, as part of the double act
The Delightful Sausage, Gledhill was nominated for Best Show at the
Edinburgh Fringe Festival's
Comedy Awards for their show
Ginsters Paradise. Between 2020 and 2021, Gledhill appeared as various characters in the
CBBC and
BBC iPlayer children's sketch show
Big Fat Like. She also contributed to the show as a writer. In 2021 and 2024, Gledhill appeared as Leslie in the
BBC Two and
BBC iPlayer comedy series ''
Alma's Not Normal''. Gledhill made her solo show debut at the 2022 Edinburgh Fringe Festival with
The Girl Before The Girl You Marry. She was nominated for Best Newcomer for that show at the Edinburgh Comedy Awards. That year she was also nominated for Best Show as part of The Delightful Sausage - she was the first person to be nominated for involvement in two shows in the same year since
Dan Antopolski in 2000. In 2023 Gledhill embarked on her first solo UK tour after a sold-out run at the
Soho Theatre in London. In January she hosted the
BBC Sounds podcast
Obsessed with... Happy Valley alongside fellow comedian
Isy Suttie, in which they "discuss fan theories and chat to familiar faces from the cast". In February Gledhill was nominated at the UK
National Comedy Awards in the Best Stand-Up category for her show
The Girl Before The Girl You Marry. She also appeared in the second series of the
Channel 4 comedy
Hullraisers. Since 2023 Gledhill is co-host on the
Northern News podcast with
Ian Smith. In February 2024, Gledhill appeared on the BBC panel comedy show
Would I Lie to You?. That month, she was nominated in the Best Best Breakthrough Act category, and
Northern News was nominated in the Best Podcast category at the
Chortle Awards. In summer 2024, Gledhill returned to the Fringe with her new show,
Make Me Look Fit on the Poster. It was nominated for Best Show at the
ISH Edinburgh Comedy Awards, and won the
Edinburgh Comedy Award for Best Show. In October 2024, Gledhill and fellow comedian
Harriet Kemsley launched a podcast called
Single Ladies In Your Area, where they discuss, with guests, modern dating after the break-up of their respective long-term relationships. In August 2025, Gledhill was announced as one of the contestants on the second series of
LOL: Last One Laughing UK, set to be released on
Amazon Prime Video in 2026. In January 2026, Gledhill appeared in the
Netflix series
Run Away as DC Ruby Todd and was announced as a contestant on the 21st series of
Taskmaster. ==Personal life==