An anastomosis is the connection of two normally divergent structures. It refers to connections between
blood vessels or between other tubular structures such as loops of
intestine.
Circulatory In
circulatory anastomoses, many arteries naturally anastomose with each other; for example, the
inferior epigastric artery and
superior epigastric artery, or the anterior and/or posterior communicating arteries in the
Circle of Willis in the brain. The circulatory anastomosis is further divided into arterial and venous anastomosis. Arterial anastomosis includes actual arterial anastomosis (e.g.,
palmar arch,
plantar arch) and potential arterial anastomosis (e.g.
coronary arteries and cortical branch of
cerebral arteries). Anastomoses also form alternative routes around
capillary beds in areas that do not need a large blood supply, thus helping regulate
systemic blood flow.
Surgical Surgical anastomosis occurs when segments of
intestine, blood vessel, or any other structure are connected together surgically (anastomosed). Examples include arterial anastomosis in
bypass surgery, intestinal anastomosis after a piece of intestine has been resected,
Roux-en-Y anastomosis and
ureteroureterostomy. Surgical anastomosis techniques include linear stapled anastomosis, hand sewn anastomosis, Anastomosis can be performed by hand or with an anastomosis assist device. Studies have been performed comparing various anastomosis approaches taking into account surgical "time and cost, postoperative anastomotic bleeding, leakage, and stricture".
Anastomotic leakage (AL) in colorectal cancer surgery Failure of an intestinal anastomosis with leakage of intestinal content in to the abdominal cavity is one of the most severe complications after bowel surgery. The severity of anastomotic leakage varies ranging from mild with minimal impact on the patient to severe and potentially fatal, with negative impact on both short- and long-term outcomes. The incidence has not changed in recent decades, despite improvement in surgical techniques, prehabilitation and perioperative care. Anastomotic leakage after rectal cancer surgery is higher and documented to occur in 9-11%, after colon resection the incidence of leakage is lower and about 6%. Systemic factors contributing to anastomotic failure include sepsis, anemia, diabetes mellitus, previous irradiation, malnutrition, steroid use, smoking, heavy alcohol consumption, obesity and certain disease conditions like Crohn's disease. Signs of an anastomotic leak include fever, abdominal pain or peritonitis, leukocytosis and tachycardia or new-onset arrythmias. Anastomotic leakage is usually diagnosed 5-8 days post-surgery. Gut microbiota, in particular, Enterococcus faecalis and Pseudomonas aeruginosa, has been shown to degrade collagen at the suture site due to high colleganase activity, therefore contributing to the pathogenesis of leakage. Patient-related factors, especially diabetes and visceral obesity, remain important independent predictors of anastomotic leakage.
Pathological Pathological anastomosis results from
trauma or
disease and may involve
veins,
arteries, or
intestines. These are usually referred to as
fistulas. In the cases of veins or arteries, traumatic fistulas usually occur between artery and vein. Traumatic intestinal fistulas usually occur between two loops of intestine (entero-enteric fistula) or intestine and
skin (enterocutaneous fistula).
Portacaval anastomosis, by contrast, is an anastomosis between a vein of the
portal circulation and a vein of the
systemic circulation, which allows blood to bypass the
liver in patients with
portal hypertension, often resulting in
hemorrhoids,
esophageal varices, or
caput medusae. ==Biology==