Kolomeisky leads a multi-disciplinary research group focused on theoretical
modeling of complex physical, chemical and biological processes using methods of statistical mechanics. He investigated in detail the dynamic properties of one-dimensional asymmetric simple exclusion processes (ASEP) and applied it for various systems Kolomeisky, together with experimental collaborators, also intensively studied the molecular transport through channels and
nanopores In addition, Kolomeisky developed a new theoretical framework for analyzing dynamics of protein-
DNA interactions. Furthermore, Kolomeisky was actively involved in theoretical studies of the formation of
morphogen gradients in biological signaling systems, of the genome interrogation by
CRISPR systems, understanding mechanisms of biological error correction, investigations of the mechanisms of cytoskeleton
protein filaments dynamics, and the dynamics of cancer formation. Kolomeisky co-authored more than 210 publications, 9 invited review papers and 5 book chapters. In 2015 he wrote a book "
Motor Proteins in Molecular Motors." He is currently the editor of the
Biophysical Journal. He also served as a guest editor for
Journal of Physics: Condensed Matter. ==Awards and honors==