•
Achille Colombo Clerici, Italian lawyer, jurist, author, and community leader •
Adolfo Colombo (1868–1953), the most recorded singer in Cuba up to 1925 •
Alain Colombo (born 1961), former French professional footballer •
Alberto Colombo (racing driver) (born 1946), former Italian racing driver •
Alfredo Colombo (1921–?), retired Italian professional football player •
Andrea Colombo (born 1974), Italian 100 metres sprinter •
Andrés Gerardo Colombo (born 1987), Argentine footballer •
Angelo Colombo (born 1961), former Italian footballer •
Angelo Martino Colombo (1935–2014), Italian professional football player •
Armando Colombo, German engineer •
Arrigo Colombo (1916–1998), Italian film producer •
Augusto Colombo (1902–1969), Italian painter •
Bartolomeo Colombo (–1515), Italian explorer •
Camila Colombo (born 1990), Uruguayan chess player •
Charles Martin Colombo (1920–1986), American soccer player •
Christine Colombo Nilsen (born 1982), Norwegian football goalkeeper •
Chrystian Colombo (born 1952), Argentine businessman and politician •
Claude Colombo (born 1960), French professional football referee •
Corrado Colombo (born 1979), Italian footballer • Cristoforo Colombo, the Italian language name of Italian explorer
Christopher Columbus (–1506) •
Domenico Colombo (Genoese: Domenego Corombo) (1418–1496), the father of navigator Christopher •
Eduardo A. Folle Colombo (1922–1994), Uruguayan basketball player •
Emilio Colombo (1920–2013), Prime Minister of Italy 1970–1972 and subsequently lifetime Senator •
Eugenio Colombo (born 1953), Italian saxophonist and flautist •
Federico Colombo (born 1987), Italian professional golfer •
Felice Colombo (born 1937), Italian businessman, past chairman of A.C. Milan (1977–80) •
Felipe Colombo Eguía (born 1983), Mexican-Argentine actor •
Filippo Colombo (born 1997), Swiss cross-country cyclist •
Franco Ermanno Colombo (1917–?), Italian professional football player •
Furio Colombo (1931–2025), Italian journalist and politician, editor-in-chief of ''L'Unità'' •
Gabriel Barcia-Colombo, American video artist •
Gabriele Colombo (born 1972), Italian road bicycle racer •
Gherardo Colombo (born 1946), Italian magistrate •
Giacomo Colombo (1663–1730), Italian sculptor, painter and engraver in the late 17th century and early 18th century in Naples. •
Gianni Colombo (1933–1993), Italian artist, member of the kinetic art movement •
Gioacchino Colombo (1903–1988), Italian automobile engine designer •
Giovanni Colombo (1902–1992), Cardinal and Archbishop of Milan •
Giovanni Battista Innocenzo Colombo (1717–1801), Swiss painter and stage set designer. •
Giuseppe Colombo (1920–1984), Italian mathematician, nicknamed "Bepi" •
Horacio Colombo (born 1934), Argentine former basketball player •
Ignacio Colombo (born 1995), Argentinian football forward •
Joe Cesare Colombo (1930–1971), Italian industrial designer •
John Robert Colombo (born 1936), Canadian author •
Joseph Anthony "Joe" Colombo Sr. (1923–1978), the boss of the Colombo crime family •
Julio Colombo (born 1984), French retired football defender •
Jürgen Colombo (born 1949), German track cyclist •
Kaitlin Colombo, American stand-up comedian, television personality, writer and actress •
Laurent del Colombo (born 1959), French judoka •
Lorenzo Colombo (born 2002), Italian footballer •
Maria Luisa Colombo (born 1952), Italian singer, best known as Lu Colombo •
Luca Colombo (cyclist) (born 1969), Italian racing cyclist •
Luca Colombo (footballer) (born 1944), Italian centre-back football player •
Luigi Colombo, Italian artist •
Marc Colombo (born 1978), former American football offensive tackle •
Marcelo Daniel Colombo (born 1961), Argentine Roman Catholic bishop of La Rioja since 2013 •
Marco Colombo (born 1960), Italian swimmer •
Maria Colombo (disambiguation), multiple people •
Martín Colombo Rivero (born 1985), Uruguayan footballer •
Nazareno Fernández Colombo (born 1997), Argentine professional footballer •
Nicola Colombo (1968–2026), Italian businessman, chairman of A.C. Monza Brianza •
Paolo Andrea Colombo (born 1960), Italian business executive •
Pia Colombo (1934–1986), French singer of Franco-Italian origin •
Raimundo Colombo (born 1955), Brazilian politician and member of the Social Democratic Party •
Realdo Colombo ( – 1559), Italian anatomist and surgeon •
Riccardo Colombo (born 1982), Italian football defender •
Roberto Colombo (footballer) (born 1975), retired Italian football goalkeeper •
Roberto Colombo (motorcyclist) (1927–1957), Italian Grand Prix motorcycle racer •
Rodrigo Jesús Colombo (born 1992), Argentine professional football defender •
Scipio Colombo (1910–2002), Italian dramatic baritone •
Simone Colombo (born 1963), former professional tennis player from Italy •
Ugo Colombo (real estate developer) (born 1961), Italian-born residential and commercial real estate developer in Miami •
Umberto Colombo (athlete) (1880–?), Italian track and field athlete •
Umberto Colombo (footballer) (1933–2021), retired Italian professional football midfielder •
Umberto Colombo (scientist) (1927–2006), Italian scientist •
Virginio Colombo (1885–1927), a prolific Italian architect later active in Buenos Aires •
Vittorino Colombo (1925–1996), Italian Christian Democrat politician •
Colombo crime family of New York •
Joseph Colombo (1923–1978), its namesake ==Football (soccer) players==