After his retirement, Mandorlini became coach of
Serie D side Manzanese in 1993, but did not manage to save them from relegation. He then was in office at
Ravenna as assistant manager until 1998, when he became head coach of
Serie C2 team
U.S. Triestina Calcio. He then joined
Spezia from 1999 to 2002, winning Serie C2 at his first season and narrowly missing promotion to
Serie B in 2002. After an eighth place with
Vicenza in their 2002–03 Serie B campaign, he joined
Atalanta and led them to promotion to
Serie A. He stayed at Atalanta for the 2003–04 campaign too, but was sacked soon after the season start. In January 2006, he was appointed at the helm of Serie B team
Bologna, but was fired two months later. In December 2006, he joined
Padova of Serie C1, leading them from the relegation zone to the battle for a spot in the promotion playoffs, then narrowly missed. In June 2007 he was announced as
Siena boss in the
2007–08 Serie A, only to be sacked on 12 November after a poor start to the season. In July 2008 he was announced as new head coach of newly promoted Serie B side
Sassuolo. He guided the
neroverdi through their debut season in the Italian second tier, leading Sassuolo to an impressive seventh place. He left Sassuolo by mutual consent in June 2009. In November 2009 he was announced as new head coach of Romanian
Liga I club
CFR Cluj. On 15 May 2010, Mandorlini guided CFR Cluj to a double: their second Romanian national title and the Romanian Cup as the first major managerial success in his career. On 15 September 2010, Andrea Mandorlini was sacked by CFR Cluj due to a poor start in the season; his dismissal was announced only days before his
UEFA Champions League debut against
FC Basel. On 9 November 2010 he was announced as new head coach of
Lega Pro Prima Divisione fallen giants
Verona, as a replacement for dismissed boss
Giuseppe Giannini. His contract with Verona was renewed until 2014 on 11 October 2011. In his Verona stint, Mandolini succeeded in winning two promotions, bringing the team back to Serie A from the third tier, and maintaining it in a safe mid-table position throughout their 2013–14 comeback season in the top flight. On 30 November 2015, Mandorlini was sacked by Hellas after five years in charge and as the longest-serving
Serie A coach at that time. On 19 February 2017, Mandorlini returned into management as new head coach of
Serie A club
Genoa in place of
Ivan Jurić, signing a one-and-a-half-year contract. On 10 April, Mandorlini was sacked and Jurić was reinstated. He was hired as manager of
Serie B club
Cremonese on 24 April 2018. He was dismissed on 4 November 2018 following a negative start to the 2018–19 Serie B campaign. On 20 January 2020, he returned to
Padova in
Serie C. After almost two years without a job, on 21 February 2023, Mandorlini returned into management as the new head coach of Serie C club
Mantova. ==Personal life==