Espiritu first worked as a DJ in the popular club, Euphoria, and was discovered by entrepreneur and musician
Ramon "RJ" Jacinto in 1990. He made his television debut on ''
That's Entertainment'', a variety show hosted by the late
German Moreno on
GMA-7. He eventually started his professional career in December 1990 when he released his debut single "Humanap Ka ng Panget" (). In mid-1997, Espiritu founded an independent rap label named Dongalo Wreckords for the purpose of discovering and producing new rap talents, one of them being the rap group
Salbakuta, with their debut single "S2upid Luv" becoming a best-seller and spawning a theatrical feature film starring Espiritu. Espiritu spent some time in
Japan in the late 1990s, performing in clubs and eventually releasing a CD single with two rap songs in
Japanese about the misadventures of a tourist in
Tokyo. This got the attention of a Japanese producer, who offered to help promote him if he would apply for Japanese citizenship. On March 25, 2002, he released the album
Porno Daw. In 2010, he was one of the judges in
ABS-CBN's noontime variety/talent show
Showtime. He later returned as a judge in the
Showtime segment "Hype Best". He has collaborated with
Sharon Cuneta,
Willie Revillame,
Joey de Leon,
Regine Velasquez,
Francis M.,
Ogie Alcasid,
Janno Gibbs,
Carlos Agassi,
Death Threat, Salbakuta, DJs such as DJ Coki of
Wil Time Big Time, DJ MOD of
Showtime and DJ Belal of New York, and actresses such as
Maricel Soriano,
Ana Roces,
Nanette Medved,
Charlene Gonzalez,
Vina Morales,
Sheryl Cruz,
Gelli de Belen,
Alice Dixson,
Amanda Page,
Rufa Mae Quinto,
Donita Rose and
Rica Peralejo. Espiritu returned to acting in 2016 as Uge, the biological father of Serena (played by
Liza Soberano) in ABS-CBN's drama series
Dolce Amore. Andrew's first Star Cinema movie was "Raketeros", a comedy movie was released in 2013 for the film company's 20th anniversary of Star Cinema and ABS-CBN Film Productions. Andrew starred alongside Dennis Padilla, Janno Gibbs, Louise Delos Reyes and Eddie Garcia in the comedy film ''Sanggano, Sanggago't Sanggwapo
, his first feature with Viva Films since A.B. Normal College
in 2003. Sanggano, Sanggago't Sanggwapo'' was released in theaters in September 2019. On December 11, 2024, Andrew held his first ever solo concert, titled
Time for your mind concert at the New Frontier Theater, Quezon City. This was the rapper first major concert in his 34 years in music industry.
Allegations of plagiarism from foreign songs In 2018, Espiritu became involved in a plagiarism controversy when "Humanap Ka ng Panget" was accused of being an unauthorized translation of the song "Find an Ugly Woman" by
DJ Cash Money and MC Marvelous. A thread in the /r/Philippines
subreddit called out the rapper for allegedly making a cover of "Find An Ugly Woman" without Cash Money Marvelous' permission, just after the noontime variety show
ASAP aired a tribute performance to Espiritu. The track "Alabang Girls" was taken from the
Led Zeppelin song "
Black Dog", where its band guitarist
Jimmy Page guest on a show of
The Tonight Show Starring Jimmy Fallon as he stated
"If someone had taken my riffs without acknowledgment or payment, it would have been deemed theft. The same standard must apply to AI". The song chorus for the track "Banyo Queen" was heavily interpolated from
Ben E. King song "Stand By Me". == Personal life ==