On ''
I'm Dying Up Here, Santino played Bill Hobbs, a talented, popular comedian who sabotages himself with a bitter attitude and negative outlook on life. From 2020 to 2023, Santino starred in the series Dave
, which tells the fictionalized story of rapper Lil Dicky; Santino portrayed his roommate and manager. In 2017, he released a Showtime special called Home Field Advantage''. Santino produces and hosts the
podcast Whiskey Ginger, where he interviews friends in the entertainment industry as they reflect on their past while sipping
whiskey. In 2020, Santino began co-hosting the
Bad Friends podcast with
Bobby Lee. Santino hosts golf content on a Youtube series called
No Bad Lies. In August 2025, Santino participated in the inaugural
Internet Invitational organized by
Barstool Sports and Bob Does Sports. In 2025, Santino participated in the
Riyadh Comedy Festival. Joey Shea, Saudi Arabia researcher at
Human Rights Watch, said in a statement that the Saudi government is using the comedy festival to
whitewash its
human rights abuses. == Filmography ==