Sepe is an Italian surname. Notable people with the surname include:Angelo Sepe, (1941–1984) Italian-American gangster Crescenzio Sepe, Italian cardinal Daniele Sepe, Italian musician Frank Sepe, American fitness author Luigi Sepe, Italian footballer Majda Sepe, (1937–2006) Slovenian singer Michele Sepe, Italian rugby player Mimmo Sepe (1955–2020), Italian comedian