Upon completing her residency, Partridge followed her husband to Boston and accepted a position at the
Dana–Farber Cancer Institute under the guidance of
Eric Winer. She also contributed to the 2006
American Society of Clinical Oncology guideline on Fertility Preservation in Cancer Patients, which led to an increase in research on the subject. As a result of her success in breast cancer research, Partridge was appointed Clinical Director of the Susan F. Smith Center for Women's Cancers Breast Oncology Program and director of the Adult Survivorship Program. She was also named to chair the
Centers for Disease Control and Prevention's Advisory Committee on Breast Cancer in Young Women. Her efforts to end breast cancer were also recognized by the
White House with one of the 2011 Champions of Change award. While serving in the role of Director for Young Women with Breast Cancer and Adult Survivorship Program at Dana-Farber, Partridge received a $1.75 million, 5-year grant for the program to continue conducting research. In addition to being the recipient to the 2018
American Association for Cancer Research's Outstanding Investigator Award for her Breast Cancer Research, she also received the 2024 European Society of Medicinal Oncology (ESMO) Award. The following year, Partridge was the recipient of the 2019 Ellen L. Stovall Award for Advancement of Cancer Survivorship Care. and Professor of Medicine at Harvard Medical School. In addition to this, Partridge is actively a Susan G. Komen Chief Scientific Advisor and a Clinical Research Professor for the American Cancer Society. ==Personal life==